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What is Amoxicillin?

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Amoxicillin is an efficient antibiotic in the class of penicillins. It works by keeping the bacteria in the body from building walls and multiplying, helping the immune system deal with the infection better.

This drug can be suitable for both adults and children, with the right dose determined based on the needs of the patient. In some cases, additional testing may be required to make sure the patient is likely to respond to this particular antibiotic and benefit from it in the way expected.

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Amoxicillin is a antibiotic group of penicillin. Amoxicillin fights bacteria in your body.

Amoxicillin is used to treat a lot of different types as infections caused by bacteria, such as infections of ear, infections of bladder, pneumonia, gonorrhea and E. coli or the infection of salmonella. Amoxicillin is so sometimes used together with clarithromycin called of another antibiotic (Biaxin) to treat ulcer of the stomach caused by the infection of pylores of Helicobacter. This combination is sometimes used with lansoprazole called of a reducing of acid of stomach (Prevacid).

Amoxicillin can also be used in purposes not listed in this guide of treatment.

Medical uses Amoxicillin

Amoxicillin is most often used for treating pneumonia, gonorrhea, infections of the middle ear, salmonella infections, bladder infections and infections that involve the presence of Escherichia coli.
Amoxicillin can also be combined with other antibiotics for treating Helicobacter pylori infections, as well as for stomach ulcer, combined with lansoprazole.

You should not be using Amoxicillin for fungal infections or infections caused by viruses, because it is not expected to work for those. Before starting the treatment, its always important to report any medical issues to the doctor, because they may affect the dose and treatment routine.

Your doctor will always need to know if you have kidney disease, liver problems, a history of asthma, allergies to any drugs, especially antibiotics, any bleeding or blood clotting disorder or mononucleosis.

Pregnant women will be able to take the medicine in most cases, as Amoxicillin is considered safe for an unborn baby, having received category B from the FDA. However, every female patient should still talk to their doctor about their pregnancy in case Amoxicillin is going to be combined with any other treatments.


Dosage and directions

Amoxicillin comes at a variety of forms and dosages to suit the needs of every patient. You may be prescribed Amoxicillin as tablets or capsules, suspension (tablets or powder) or chewable tablets.

Whether you are prescribed powder or tablets will depend on your needs and preferences: measuring the right dose here is crucial for successful treatment. Chewable tablets can contain 125, 200, 250 or 400 mg of Amoxicillin. Tablets can contain either 500 or 875 mg of Amoxicillin, while capsules can be purchased at the dose of 250 or 500 mg. The lowest dose administered is usually 200 mg, the highest is 875 mg.
Every dose is supposed to be taken as prescribed, at regular intervals, up to three times a day. The treatment period can be as short as one week and as long as two weeks. It's important to continue the treatment until you have used the entire amount of Amoxicillin prescribed, because improved symptoms do not mean the infection cleared up.

You should take your regular dose of Amoxicillin with a full glass of water, with some food or without. It's important to avoid alcohol when taking Amoxicillin, as some of the possible side effects may be worsened as a result. You should not combine Amoxicillin with azithromycin, blood thinners, tetracycline antibiotics, probenecid, erythromycin, clarithromycin or sulfa drugs, because interactions have been reported.

Usual Adult Dose for Actinomycosis

500 mg orally 3 times a day or 875 mg orally twice a day for six months
Initial treatment of actinomycosis should include high dose parenteral penicillin G or ampicillin for 4 to 6 weeks, followed by appropriate oral therapy.

Usual Adult Dose for Anthrax Prophylaxis

500 mg orally every 8 hours

Oral amoxicillin is not considered first-line treatment for anthrax prophylaxis; it may, however, be used to complete a 60-day prophylactic course after 10 to 14 days of ciprofloxacin or doxycycline in pregnant or lactating patients or in patients with contraindications to the other two agents. The total duration of antimicrobial therapy is 60 days.

Usual Adult Dose for Cutaneous Bacillus anthracis

Treatment for confirmed cases of cutaneous Bacillus anthracis infection: 500 mg orally three times a day

Oral amoxicillin is not considered first-line treatment for the treatment of cutaneous anthrax; it may, however, be used to complete the treatment course once clinical response to ciprofloxacin or doxycycline has been observed or if the patient has contraindications to the other two agents. The total duration of antimicrobial therapy is 60 days.

Usual Adult Dose for Bacterial Endocarditis Prophylaxis

2 g orally given one hour prior to the procedure

Amoxicillin is considered the standard agent for prophylaxis against bacterial endocarditis in at-risk individuals undergoing certain dental, oral, respiratory tract or esophageal procedures.

Amoxicillin is not appropriate as endocarditis prophylaxis for patients identified as high-risk, including those with prosthetic heart valves, prior endocarditis, and those who have had surgically constructed systemic shunts or conduits. These patients should receive appropriate parenteral antimicrobial therapy.

Usual Adult Dose for Chlamydia Infection

500 mg orally 3 times a day for 7 days in pregnant patients as an alternative to erythromycin in macrolide-sensitive individuals

Amoxicillin does not have reliable activity against Chlamydia trachomatis.

Usual Adult Dose for Cystitis

250 to 500 mg orally 3 times a day for 3 to 7 days; alternatively, 500 to 875 mg orally twice a day may be administered

Usual Adult Dose for Urinary Tract Infection

250 to 500 mg orally 3 times a day for 3 to 7 days; alternatively, 500 to 875 mg orally twice a day may be administered

Usual Adult Dose for Helicobacter pylori Infection

1 g orally 2 to 3 times a day for 14 days
Amoxicillin is used in combination with metronidazole and bismuth subsalicylate or with clarithromycin and a proton-pump inhibitor such as omeprazole or lansoprazole.

Usual Adult Dose for Lyme Disease - Arthritis

500 mg orally 3 times a day for 14 to 30 days
Early Lyme disease is often treated with an oral antibiotic such as doxycycline, cefuroxime or azithromycin, all of which are active against Borrelia burgdorferi. If amoxicillin is used, clinicians may wish to add probenecid, although the benefit of this addition is uncertain.

Up to 15% of patients with Lyme disease experience the Jarisch-Herxheimer reaction (increased fever, increased flushing rash, and increased pain) during the first 24 hours of therapy. This reaction is self-limiting, does not necessarily reflect true allergy to amoxicillin, and may be reduced in intensity by premedication with aspirin and/or prednisone.

Usual Adult Dose for Lyme Disease - Carditis

500 mg orally 3 times a day for 14 to 30 days
Early Lyme disease is often treated with an oral antibiotic such as doxycycline, cefuroxime or azithromycin, all of which are active against Borrelia burgdorferi. If amoxicillin is used, clinicians may wish to add probenecid, although the benefit of this addition is uncertain.

Up to 15% of patients with Lyme disease experience the Jarisch-Herxheimer reaction (increased fever, increased flushing rash, and increased pain) during the first 24 hours of therapy. This reaction is self-limiting, does not necessarily reflect true allergy to amoxicillin, and may be reduced in intensity by premedication with aspirin and/or prednisone.

Usual Adult Dose for Lyme Disease - Erythema Chronicum Migrans

500 mg orally 3 times a day for 14 to 30 days
Early Lyme disease is often treated with an oral antibiotic such as doxycycline, cefuroxime or azithromycin, all of which are active against Borrelia burgdorferi. If amoxicillin is used, clinicians may wish to add probenecid, although the benefit of this addition is uncertain.

Up to 15% of patients with Lyme disease experience the Jarisch-Herxheimer reaction (increased fever, increased flushing rash, and increased pain) during the first 24 hours of therapy. This reaction is self-limiting, does not necessarily reflect true allergy to amoxicillin, and may be reduced in intensity by premedication with aspirin and/or prednisone.

Usual Adult Dose for Lyme Disease - Neurologic

500 mg orally 3 times a day for 14 to 30 days
Early Lyme disease is often treated with an oral antibiotic such as doxycycline, cefuroxime or azithromycin, all of which are active against Borrelia burgdorferi. If amoxicillin is used, clinicians may wish to add probenecid, although the benefit of this addition is uncertain.

Up to 15% of patients with Lyme disease experience the Jarisch-Herxheimer reaction (increased fever, increased flushing rash, and increased pain) during the first 24 hours of therapy. This reaction is self-limiting, does not necessarily reflect true allergy to amoxicillin, and may be reduced in intensity by premedication with aspirin and/or prednisone.

Usual Adult Dose for Otitis Media

250 to 500 mg orally 3 times a day for 10 to 14 days; alternatively, 500 to 875 mg orally twice a day may be administered

Usual Adult Dose for Pneumonia

500 mg orally 3 times a day or 875 mg orally twice a day may be administered for 7 to 10 days if pneumococcal pneumonia is suspected
Only mild pneumonia due to pneumococcus should be treated with amoxicillin.

Usual Adult Dose for Sinusitis

250 to 500 mg orally 3 times a day for 10 to 14 days; alternatively, 500 to 875 mg orally twice a day may be administered
Longer courses of therapy, up to 3 or 4 weeks, may be required in refractory or recurrent cases.

Usual Adult Dose for Skin or Soft Tissue Infection

250 to 500 mg orally 3 times a day for 7 to 10 days; alternatively, 500 to 875 mg orally twice a day may be administered

Usual Adult Dose for Upper Respiratory Tract Infection

250 to 500 mg orally 3 times a day for 7 to 10 days; alternatively, 500 to 875 mg orally twice a day may be administered

Usual Adult Dose for Bronchitis

250 to 500 mg orally 3 times a day for 7 to 10 days; alternatively, 500 to 875 mg orally twice a day may be administered

Usual Adult Dose for Tonsillitis/Pharyngitis

Immediate-release: 250 to 500 mg orally 3 times a day for 7 to 10 days; alternatively, 500 to 875 mg orally twice a day may be administered
Extended-release: 775 mg orally once a day within 1 hour after a meal for 10 days; for infections secondary to Streptococcus pyogenes

Usual Adult Dose for Bacterial Infection

250 to 500 mg orally 3 times a day for 7 to 21 days; alternatively, 500 to 875 mg orally twice a day may be administered

Usual Pediatric Dose for Bacterial Endocarditis Prophylaxis

50 mg/kg orally as a single dose 1 hour prior to procedure

Amoxicillin is not appropriate as endocarditis prophylaxis for patients identified as high-risk, including those with prosthetic heart valves, prior endocarditis, and those who have had surgically constructed systemic shunts or conduits. These patients should receive appropriate parenteral antimicrobial therapy.

Usual Pediatric Dose for Anthrax Prophylaxis

80 mg/kg/day divided into equal doses administered orally every 8 hours
Maximum dose: 500 mg/dose

Oral amoxicillin is not considered first-line treatment for anthrax prophylaxis; it may, however, be used to complete a 60-day prophylactic course after 10 to 14 days of ciprofloxacin or doxycycline in pediatric patients. The total duration of antimicrobial therapy is 60 days.

Usual Pediatric Dose for Cutaneous Bacillus anthracis

Treatment for confirmed cases of cutaneous Bacillus anthracis infection: 80 mg/kg/day divided into equal doses administered orally every 8 hours
Maximum dose: 500 mg/dose

Oral amoxicillin is not considered first-line treatment for the treatment of cutaneous anthrax; it may, however, be used to complete the treatment course once clinical response to ciprofloxacin or doxycycline has been observed. The total duration of antimicrobial therapy is 60 days.

Usual Pediatric Dose for Otitis Media

4 weeks to 3 months: 20 to 30 mg/kg/day in divided doses every 12 hours
4 months to 12 years: 20 to 50 mg/kg/day in divided doses every 8 to 12 hours; acute otitis media due to highly resistant strains of Streptococcus pneumonia may require doses of 80 to 90 mg/kg/day orally divided into 2 equal doses 12 hours apart

Usual Pediatric Dose for Skin or Soft Tissue Infection

4 weeks to 3 months: 20 to 30 mg/kg/day in divided doses every 12 hours
4 months to 12 years: 20 to 50 mg/kg/day in divided doses every 8 to 12 hours; acute otitis media due to highly resistant strains of Streptococcus pneumonia may require doses of 80 to 90 mg/kg/day orally divided into 2 equal doses 12 hours apart

Usual Pediatric Dose for Urinary Tract Infection

4 weeks to 3 months: 20 to 30 mg/kg/day in divided doses every 12 hours
4 months to 12 years: 20 to 50 mg/kg/day in divided doses every 8 to 12 hours; acute otitis media due to highly resistant strains of Streptococcus pneumonia may require doses of 80 to 90 mg/kg/day orally divided into 2 equal doses 12 hours apart

Usual Pediatric Dose for Pneumonia

40 to 50 mg/kg/day orally in divided doses every 8 hours

Usual Pediatric Dose for Tonsillitis/Pharyngitis

4 weeks to 3 months: 20 to 30 mg/kg/day in divided doses every 12 hours
4 months to 12 years: 20 to 50 mg/kg/day in divided doses every 8 to 12 hour

12 years or older:
Immediate-release: 250 to 500 mg orally 3 times a day for 7 to 10 days; alternatively, 500 to 875 mg orally twice a day may be administered
Extended-release: 775 mg orally once a day within 1 hour after a meal for 10 days; for infections secondary to S pyogenes

Renal Dose Adjustments

CrCl 10 to 30 mL/min: 250 to 500 mg orally every 12 hours
CrCl 9 mL/min or less: 250 to 500 mg orally every 24 hours

The 875 mg tablets and the 775 mg extended-release tablets should not be given to patients with CrCl less than 30 mL/min.

Liver Dose Adjustments

Data not available

Precautions

The drug should be discontinued immediately at the first appearance of a skin rash or other signs of hypersensitivity.

Clostridium difficile associated diarrhea (CDAD) has been reported with almost all antibiotics and may potentially be life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea following amoxicillin therapy. Mild cases generally improve with discontinuation of the drug, while severe cases may require supportive therapy and treatment with an antimicrobial agent effective against C difficile. Hypertoxin producing strains of C difficile cause increased morbidity and mortality; these infections can be resistant to antimicrobial treatment and may necessitate colectomy.

Dose reductions are recommended in patients with severe renal impairment. It may be advisable to monitor renal function in elderly patients.

Periodic monitoring of renal, hepatic, and hematologic function is recommended in all patients during prolonged therapy.

Patients with phenylketonuria should be aware that amoxicillin chewable tablets contain phenylalanine (1.82 mg/200 mg tablet and 3.64 mg/400 mg tablet). The 200 and 400 mg tablets for oral suspension contain 5.6 mg phenylalanine per tablet.

The immediate-release formulations should not be substituted for the extended-release tablets.

Amoxicillin is not effective for the treatment of syphilis, although it may mask or delay its symptoms when used to treat gonorrhea. All gonorrhea patients should undergo serologic testing for syphilis at the time of diagnosis and 3 months after treatment.

The safety and efficacy of the extended-release tablets have not been established in patients less than 12 years of age.

Dialysis

Adults, conventional hemodialysis: 250 to 500 mg every 24 hours with supplemental doses during and after a hemodialysis session

The 775 mg extended-release tablets are not recommended for patients on hemodialysis.

Other Comments

At least 10 days of therapy is recommended for infections caused by S pyogenes to prevent acute rheumatic fever.

Immediate-release amoxicillin may be given without regard to meals. The extended-release tablets should be taken within 1 hour of finishing a meal at about the same time each day.

The oral suspension may be mixed with formula, milk, fruit juice, ginger ale, or cold drinks, and should be taken immediately after mixing.

The suspension should be discarded 14 days after reconstitution.

The tablets for oral suspension should not be chewed or swallowed whole. The dispersible tablets for oral suspension should be mixed with 2 teaspoonfuls of water, the patient should drink the entire mixture, then a small amount of water should be used to rinse the container, and the patient should drink this also. The extended-release tablets should not be chewed or crushed.

Important information about Amoxicillin

Do not use this treatment if you are allergic in amoxicillin or in other antibiotic of penicilline, such as ampicillin (Omnipen, Principen), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.

Before using amoxicillin, say to your doctor if you are allergic to cephalosporins such as Omnicef, Cefzil, Ceftin, Keflex and others. Said also to your doctor if you have asthma, the liver or the illness of the kidney, a bleeding or the blood coagulating riot, the mononucleosis (also called "mono"), or any type of allergy.

Amoxicillin can return less efficient contraceptive pills. Ask your doctor of the use of a method of non-hormone for the birth control (for such as for a condom, for a diaphragm, for a spermicide) to tell the pregnancy by taking amoxicillin. Take this treatment for full prescribed term. Your symptoms can improve before the infection is completely clear. Amoxicillin will not treat a viral infection such as head cold or influenza. Do not share this treatment with another person, even if they have the same symptoms which you have.

Medicines antibiotics can cause the diarrhea, which can be a sign of a new infection. If you have the diarrhea which is saturated with water or covered with blood, give up taking amoxicillin and call your doctor. Do not use the medicine of anti-diarrhea unless your doctor says to.

Before taking Amoxicillin

Do not use this medicament if you are allergic to the amoxicillin or to quite other antibiotic of penicillin, such as:

asthma;

liver disease;

kidney disease;

mononucleosis (also called "mono");

a history of diarrhea caused by taking antibiotics; or

a history of any type of allergy.

To assure you that you can without risk take the amoxicillin, speak about it to your doctor if you are allergic to medicaments (especially cephalosporines such as Omnicef, Cefzil, Ceftin, Keflex, and others), or if you have one of these other conditions:

asthma;

an illness of the liver;

a renal illness;

mononucleosis (also called "mono");

a history of diarrhea caused by the catch of antibiotics, or

a history of any type of allergy.

FDA pregnancy category B. The amoxicillin should not harm a baby to be born. Say to your doctor if you are pregnant or plan to become pregnant during the treatment. The amoxicillin can take the less efficient contraceptive pill. Ask your doctor on the use of a not hormonal method of birth control (as for a condom, for diaphragm, for spermicide) to tell the pregnancy while taking the amoxicillin. The amoxicillin can pass in the maternal milk and can harm the baby. Do not use this medicament without speaking about it to your doctor if you nurse a baby.

How should I take amoxicillin?

Take the amoxicillin exactly as prescribed by your doctor. Do not take in bigger or smaller quantities or longer than recommended. Follow instructions on your tag of prescript.

You can take the amoxicillin 500mg with or without food.

To agitate oral suspension (liquidates) and just before measuring you a dose. To measure the liquid with a special dose crams to measure spoon or medicine, not with a spoon of ordinary table. If you have no device of dose-measure, ask your chemist.

You can put the liquid directly on the language, or you can blend it with some water, the milk, the mother's milk substitute, the fruit juice or soda in the ginger. Drink all mixture right away. Do not record everything for a subsequent use.

The chewable tablet must be chewed before swallowing it.

Do not crush, chew, or break an extended-release tablet. Swallow completely. To break the pill can cause some drug too much is necessary be published at some point.

To be sure that this medicament is to help your condition and does not talk about damaging effects, your blood will have to be often tested. Your liver function and renal are also possible need to be tested. Visit your doctor regularly.

If you are treated for the gonorrhea, your doctor also can you screening of syphilis, another sexually transmitted disease.

If you take the amoxicillin with the clarithromycine and / or lansoprazole to treat the ulcer of the stomach, to use all your medicaments according to directives. Read the guide of instructions to the patient a medicament or given with every medicament. Do not change your dose or the calendar of medicaments without the opinion of your doctor.

Take the amoxicillin for the duration prescribed of time. Your symptoms can improve before the infection is completely erased. The amoxicillin will not be treat a viral infection as cold or influenza. Do not share this medicament with another person, even if they have the same symptoms which you have.

The amoxicillin can cause unusual results with some medical tests. Say to every doctor who treats you that you use this medicament.

Stock this medicament at room temperature far from humidity, from heat and from light. You can stock the liquid amoxicillin in the refrigerator, but do not allow him to freeze. To throw any amoxicillin liquidates which is not used in 14 days having been blended in the chemist's shop.

What to do if I miss a dose Amoxicillin?

Take the forgotten dose as soon as you remember. Skip the forgotten dose if he is almost time for your next programmed dose. Do not take additional medicine to compensate for the forgotten dose.

What to do if I overdose Amoxicillin?

Search an urgent medical attention or call the help line of poison has +1-646-205-2937.

The symptoms of excessive dose include confusion, changes of behavior, a strict cutaneous eruption, to urinate less than usually, or seizure (blackout or of convulsions).

What must I avoid during the amoxicillin acceptance?

Antibiotic medicines can cause the diarrhea , which can be a sign of a new infection. If you have the diarrhea which is aqueous or bloody, give up taking the amoxicillin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Side effects Amoxicillin

Get the urgent health care if you have one of these signs of a reaction allergic to the amoxicillin: hives, difficulty in breathing, swelling of your face, lips, language, or throat. Call your doctor immediately if you have a serious side effect such as:

white patches or sores inside your mouth or on your lips;

fever, swollen glands, rash or itching, joint pain, or general ill feeling;

severe blistering, peeling, and red skin rash;

pale or yellowed skin, yellowing of the eyes, dark colored urine, fever, confusion or weakness;

severe tingling, numbness, pain, muscle weakness; or

easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin.

Less serious side effects amoxicillin can include:

troubles of stomach, nausea, vomiting;

itches or vaginal losses;

headaches, or

swollen, black, or "hairy" tongue.

This is not a complete list of side effects Amoxicillin 500mg and others may occur. Call your doctor for medical advice about antibiotic's side effects.

What other pills will affect amoxicillin?

Tell to your doctor all other medicaments which you use, especially:

probenecid (Benemid);

a blood thinner such as warfarin (Coumadin);

an antibiotic such as azithromycin (Zithromax), clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);

sulfa drugs (Bactrim, Gantanol, Gantrisin, Septra, SMX-TMP, and others); or

a tetracycline antibiotic such as demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not exhaustive and of other drugs is possible interact with the amoxicillin. Tellto your doctor all medicaments which you use. It includes prescription on amoxicillin, products over-the-counter, of vitamins, and herbs. Do not begin a new medicament without speaking about it to your doctor.

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